Infertility is a rapidly growing global health issue with far-reaching socioeconomic impacts. The success rates of treatment through assisted reproductive technologies has plateaued at ~33% per cycle. Our focus is the development of microfluidics-based male fertility treatment. This effort is made possible through close collaboration between our engineering researchers and collaborating urology and clinical fertility experts. The challenge of sperm selection for assisted reproduction is the large number of candidate sperm and their relatively short lifetime in vitro. Comprehensive selection of the best sperm requires noninvasive assessment of individual cells at cell sorting rates orders of magnitude higher than currently available. We are taking a two-pronged approach to this challenge: we use dense microfluidic labyrinth structures to select a small sub-population of high quality motile sperm, and then apply deep learning based image analysis for the final selection.
Selected Recent Publications
McCallum, C., Riordon, J., Wang, Y., Kong, T., You, J.B., Sanner, S., Lagunov, A., Hannam, T.G., Jarvi, K., Sinton, D., Communications Biology 2, 250, (2019), https://doi.org/10.1038/s42003-019-0491-6
Riordon, J., McCallum, C., and Sinton, D., Deep learning for the classification of human sperm, Computers in Biology and Medicine, Accepted June 22, 2019.
Wang, Y., Riordon, J., Kong, T., Xu, Y., Nguyen, B., Zhong, J., You, J.B., Lagunov, A., Hannam, T.G., Jarvi, K., and Sinton, D., Advanced Science 1900712, (2019), https://doi.org/10.1002/advs.201900712
Riordon, J., Tarlan, F., You, J.B., Zhang, B., Graham, P.J., Kong, T., Wang, Y., Lagunov, A., Hannam, T., Jarvi, K. and Sinton, D. Lab on a Chip 19, no. 13, 2161-2167, (2019), DOI: 10.1039/C9LC00209J
Kong, T., You, J.B., Zhang, B., Nguyen, B., Tarlan, F., Jarvi, K. and Sinton, D., Lab on a Chip, 2019, 19, 1991 - 1999 . DOI: 10.1039/C9LC00165D
You, J. B., Wang, Y., McCallum, C., Tarlan, F., Hannam, T., Lagunov, A., Jarvi, K., and Sinton, D. Lab on a Chip, 19, 815-824, (2019), DOI: 10.1039/c8lc01204k
Riordon, J., Sovilj, D., Sanner, S., Sinton, D., and Young, E.W.K. Trends in Biotechnology 37, no. 3, 310–324, (2019), https://doi.org/10.1016/j.tibtech.2018.08.005.
Nosrati, R., Graham, P. J., Zhang, B., Riordon, J., Lagunov, A., Hannam, T. G., Escobedo, C., Jarvi, K. and Sinton, D. Nature Reviews Urology, (2017), 14, 707-730, DOI: 10.1038/nrurol.2017.175.
Gong, M. and Sinton, D. Chemical Reviews, 117 (12), 8447–8480, (2017), DOI: 10.1021/acs.chemrev.7b00024.