The rise of atmospheric greenhouse gases has led to a changing climate, where living organisms and ecosystems are subject to very different environmental parameters including gases (CO2, CH4 and O2), aqueous chemicals (nutrients, salinity, organic pollutants, and pH), solar irradiance, and temperature. Understanding how these many environmental variables act in concert to promote, inhibit or otherwise affect individual organisms, populations, communities and ecosystems is a critically important challenge not addressable with current methods. No current methods can achieve the 1000+ parallel treatments required to address the full factorial multi-parameter challenge inherent to climate change. Our focus is on full-factorial screening capable of quantifying the response of model microorganisms, flora and fauna to key environmental variables - gases (CO2, CH4 and O2), aqueous chemicals (nutrients, salinity, toxins, pH) and solar irradiance at relevant temperatures. The approach leverages our ability to control gas conditions over 100s and 1000s of microwells simultaneously.